Traduction de «such variants can be » (Néerlandais → Français) :

The clinical significance of heterogeneous glycopeptide intermediate S. aureus (hGISA; borderline susceptible strains) is unclear, although recent data suggest that the response to the glycopeptide therapy administered to patients infected by such variants can be poor.
La signification clinique de S. aureus intermédiaire aux glycopeptides hétérogènes (hGISA; les souches sensibles limites) est peu claire bien que les données récentes suggèrent que la réponse à la thérapie aux glycopeptides des patients infectés par de telles variantes peut être insuffisante.

Moreover, hGISA can easily select GISA variants in patients being given a prolonged glycopeptide therapy.
D'ailleurs, hGISA peut aisément choisir des variantes de GISA chez les patients sous thérapie prolongée aux glycopeptides.

This release contains forward-looking information about an agreement by Pfizer to acquire FoldRx, and about FoldRx’s product candidate tafamidis, its other clinical and preclinical development programs and its technology platform, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the satisfaction of conditions to closing the agreement; the uncertainties inherent in research and development; whether and when a new drug application for tafamidis will be filed with the FDA; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for tafamidis and that may be filed for any other product candidates that may be generated by FoldRx’s technology platform as well as their decisions regarding labeling and other matters that could affect the availability or commercial potential of tafamidis and such other product candidates; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2009 and in its reports on Form 10-Q and Form 8-K.
Such risks and uncertainties include, among other things, the satisfaction of conditions to closing the agreement; the uncertainties inherent in research and development; whether and when a new drug application for tafamidis will be filed with the FDA; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for tafamidis and that may be filed for any other product candidates that may be generated by FoldRx’s technology platform as well as their decisions regarding labeling and other matters that could affect the availability or commercial potential of tafamidis and such other product candidates; and competitive developments.

Experts point out that such an intake can cause temporary behaviour changes, such as agitation, irritability, nervousness or anxiety, in short, effects that typically accompany caffeine consumption (Nawrot et al., 2003).
Selon ces experts, un tel apport peut causer des modifications comportementales transitoires telles de l’agitation, de l’irritabilité, de la nervosité ou de l’anxiété, effets typiquement liés à une consommation de caféine (Nawrot et al., 2003).

However, it does not go on to assess the innocuousness of energy drinks as such. Owing to the absence of new data concerning chronic and acute exposure, the exposures used in this advisory report are based on an average daily chronic consumption of 0.5 can per person and a high chronic exposure of 1.4 cans for a regular consumer.
En l’absence de nouvelles informations sur l’exposition chronique et aiguë, les expositions utilisées dans l’avis ont reposé sur une consommation chronique journalière moyenne de 0,5 canette par personne et une exposition chronique élevée de 1,4 canettes pour un consommateur régulier.

However, some data, such as those of the 2004 health survey mentioned above, can provide us with some items of information.
Cependant, certaines données telles que celles de l’enquête santé de 2004 déjà évoquée peuvent nous fournir quelques éléments d’information.

However, the impact of some risk factors can clearly be reduced by certain interventions such as providing lithium for manicdepressive illness or strengthening social support in a community (Baldessarini, Tando, & Hennen, 1999).
Néanmoins, il est clair que l’impact de certains facteurs de risque peut être réduit par certaines interventions comme fournir du lithium pour les troubles maniaco-dépressifs ou renforcer le soutien social dans une communauté (Baldessarini, Tando, Hennen, 1999).

Whereas there were 58 programmable inspections (routine + new inspections) of GMP companies in 2007, the increase in the number of personnel during the year means that 122 such inspections can be planned for 2008.
Whereas there were 58 programmable inspections (routine + new inspections) of GMP companies in 2007, the increase in the number of personnel during the year means that 122 such inspections can be planned for 2008.

It is important that the most promising products are identified so that available means (such as time, trial animals, working time, money) can quickly be concentrated on further development of these products.
It is important that the most promising products are identified so that available means (such as time, trial animals, working time, money) can quickly be concentrated on further development of these products.

Risk factors that cannot be changed (such as a previous attempted suicide) can alert others to the heightened risk of suicide during periods of the recurrence of a mental or substance abuse disorder following a particularly stressful life event (Oquendo et al., 1999).
Les facteurs de risque qui ne peuvent pas être changés (comme les tentatives de suicide antérieures) peuvent alerter les autres du risque accru de suicide durant des périodes de récurrence de troubles mentaux ou d’abus de substances à la suite d’un événement de vie particulièrement stressant (Oquendo et al., 1999).