Traduction de «research and experimental development » (Néerlandais → Français) :

OESO, Measuring Expenditure on Health-related R&D, 2001 en OESO, Frascati Manual 2002, The Measurement of Scientifi c and Technological Activities, Proposed Standard Practice for Surveys on Research and Experimental Development, 2002.
OCDE, Measuring Expenditure on Health-related R&D, 2001, et Frascati Manual 2002, The Measurement of Scientifi c and Technological Activities, Proposed Standard Practice for Surveys on Research and Experimental Development.

This release contains forward-looking information about an agreement by Pfizer to acquire FoldRx, and about FoldRx’s product candidate tafamidis, its other clinical and preclinical development programs and its technology platform, including their potential benefits, that involves substantial risks and uncertainties. Such risks and uncertainties include, among other things, the satisfaction of conditions to closing the agreement; the uncertainties inherent in research and development; whether and when a new drug application for tafamidis will be filed with the FDA; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for tafamidis and that may be filed for any other product candidates that may be generated by FoldRx’s technology platform as well as their decisions regarding labeling and other matters that could affect the availability or commercial potential of tafamidis and such other product candidates; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2009 and in its reports on Form 10-Q and Form 8-K.
Such risks and uncertainties include, among other things, the satisfaction of conditions to closing the agreement; the uncertainties inherent in research and development; whether and when a new drug application for tafamidis will be filed with the FDA; decisions by regulatory authorities regarding whether and when to approve any drug applications that have been or may be filed for tafamidis and that may be filed for any other product candidates that may be generated by FoldRx’s technology platform as well as their decisions regarding labeling and other matters that could affect the availability or commercial potential of tafamidis and such other product candidates; and competitive developments.

Impairments: Cost of Goods Sold includes impairment charges for acquired rights to in-market products and other production-related impairment charges, including an additional reversal of USD 100 million for an impairment charge taken in 2007 for Famvir; Research & Development includes write-offs related to in-process Research & Development, mainly a USD 584 million charge for the discontinuation of Mycograb and Albuferon development projects and a net pre-tax impairment charge of USD 152 million (USD 250 million related to the value of the intangible asset offset by a release of a USD 98 million liability related to the estimated value of a contingent milestone consideration) for termination of the PTZ601 development project; Other income includes the reversal of impairments, primarily for financial assets; Other expense includes impairments, primarily for financial assets.
Coût des ventes comprend des charges pour pertes de valeur sur des droits acquis de produits commercialisés et d’autres charges pour pertes de valeur liées à la production, y compris la reprise supplémentaire d’USD 100 millions pour une charge pour pertes de valeur comptabilisée en 2007 sur Famvir; Recherche et développement comprend des dépréciations liées à des projets en cours de développement , principalement une charge d’USD 584 millions pour la cessation des projets Mycograb et Albuferon et une charge nette avant impôts pour perte de valeur d’USD 152 millions (un montant d’USD 250 millions lié à la valeur de l’immobilisation incorporelle et contrebalancé par la dissolution d’un passif d’USD 98 millions lié à la valeur estimée d’un paiement d’étape éventuel) pour la cessation du projet PTZ601 en développement; Autres produits comprend la reprise de pertes de valeur, principalement sur des actifs financiers; Autres charges comprend des pertes de valeur, principalement sur des actifs financiers.

FoldRx is a development and discovery company focusing on first-in-class, disease-modifying, small molecule therapeutics to treat diseases of protein misfolding and aggregation (amyloidosis) based on the pioneer work of its scientific founders, Jeffery Kelly (The Scripps Research Institute) and Susan Lindquist (Whitehead Institute).
folding and its platform for drug and target discovery, the company is building a pipeline, initially for neurodegenerative and respiratory conditions. FoldRx’s pipeline includes a program in advanced clinical development to treat genetic neurologic and cardiovascular disorders, Transthyretin (TTR) Amyloid Polyneuropathy (ATTR-PN) and TTR Amyloid Cardiomyopathy (ATTR-CM), and a discovery program in cystic fibrosis, Parkinson’s, and Huntington’s disease based on its broad, proprietary, yeast-based drug discovery platform.

Impairments: Cost of Goods Sold includes impairment charges for acquired rights to in-market products and other production-related impairment charges; Research & Development includes write-offs related to inprocess Research & Development, thereof a USD 584 million charge for the discontinuation of Mycograb and Albuferon development projects; Other income includes adjustments to impairments, primarily for property, plant & equipment; Other expense includes impairments, primarily for financial assets.
Pertes de valeur: Coût des ventes comprend des charges pour pertes de valeur sur des droits acquis de produits commercialisés et d’autres charges pour pertes de valeur liées à la production; Recherche et développement comprend des dépréciations liées à des projets en cours de développement, principalement une charge d’USD 584 millions pour la cessation des projets Mycograb et Albuferon; Autres produits comprend des ajustements des pertes de valeur, principalement pour des immobilisations corporelles; Autres charges comprend des pertes de valeur, principalement sur des actifs financiers.

Pfizer Biotherapeutics en Pfizer Pharmatherapeutics Research & Development telt vijf belangrijke vestigingen, vier in de Verenigde Staten en één in Engeland.
Pfizer Biotherapeutics et Pharmatherapeutics Research & Development possède cinq sites majeurs – quatre aux Etats-Unis et un en Grande-Bretagne.

Pfizers toonaangevende onderzoeks- en ontwikkelingscentra in Groton maken Connecticut tot de hoofdvestiging van Pfizer Research & Development.
Le centre de recherche et de développement pionnier de Groton fait du Connecticut le cœur de Pfizer Biotherapeutics et Pharmatherapeutics Research & Development.

De Europese hoofdvestiging van Biotherapeutics en Pharmatherapeutics Research & Development in het Engelse Sandwich speelt een belangrijke rol in de ontwikkeling van nieuwe Pfizer-geneesmiddelen.
Le siège européen de Pfizer Biotherapeutics et Pharmatherapeutics Research & Development , situé à Sandwich, en Grande-Bretagne, joue un rôle prépondérant dans le développement de nouveaux médicaments Pfizer.

Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; whether and when regulatory authorities in countries where regulatory applications for Prevenar 13 may be pending or may be submitted will approve such applications and their decisions regarding labeling and other matters that could affect its availability or commercial potential; and competitive developments.
This release contains forward-looking information that involves substantial risks and uncertainties regarding Prevenar 13, including its potential benefits; and the success of the AMC project for vaccines. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; whether and when regulatory authorities in countries where regulatory applications for Prevenar 13 may be pending or may be submitted will approve such applications and their decisions regarding labeling and other matters that could affect its availability or commercial potential; and competitive developments. A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2009, and in its reports on Form 10-Q and Form 8-K.