Vertaling van "cost-effectiveness of bupropion " (Nederlands → Frans) :

36. Woolacott NF, Jones L, Forbes CA, Mather LC, Sowden AJ, Song FJ et al. The clinical effectiveness and cost-effectiveness of bupropion and nicotine replacement therapy for smoking cessation: a systematic review and economic evaluation.
36. Woolacott NF, Jones L, Forbes CA, Mather LC, Sowden AJ, Song FJ et al. The clinical effectiveness and cost-effectiveness of Bupropion and nicotine replacement therapy for smoking cessation: a systematic review and economic evaluation.

Odds ratio of NRT versus control: 1.67 Odds ratio of bupropion versus control: 2.1 Odds ratio of NRT+bupropion versus control: 2.65 From these Odds Ratios and information on the control 12-month quit rate in the comparator intervention (0.04 for brief advice and 0.10 for counselling), the 12-month quit rate of treatment is calculated: treated quit rate for brief advice+NRT: 0.0650 treated quit rate for brief advice+bupropion: 0.0805 treated quit rate for brief advice+bupropion+NRT: 0.0994 treated quit rate for counselling+NRT: 0.1565 treated quit rate for counselling+bupropion: 0.1892 treated quit rate for counselling+bupropion+NRT: 0.2275 spontaneous cessation rate: 0.01. lifetime relapse rate: 40% (range 30-50%). number of LYG per quitter: 2 (range 1-3). number of QALYs gained per quitter: 2.7 (range 1.35-4.05) not reported The table gives an overview of the assumptions with respect to costs and effects (quit rates) in the average scenario.
Odds ratio of NRT versus control: 1.67 Odds ratio of Buproprion versus control: 2.1 Odds ratio of NRT+Buproprion versus control: 2.65 From these Odds Ratios and information on the control 12-month quit rate in the comparator intervention (0.04 for brief advice and 0.10 for counselling), the 12-month quit rate of treatment is calculated: treated quit rate for brief advice+NRT: 0.0650 treated quit rate for brief advice+Buproprion: 0.0805 treated quit rate for brief advice+Buproprion+NRT: 0.0994 treated quit rate for counselling+NRT: 0.1565 treated quit rate for counselling+Buproprion: 0.1892 treated quit rate for counselling+Buproprion+NRT: 0.2275 spontaneous cessation rate: 0.01. lifetime relapse rate: 40% (range 30-50%). number of LYG per quitter: 2 (range 1-3). number of QALYs gained per quitter: 2.7 (range 1.35-4.05) not reported The table gives an overview of the assumptions with respect to costs and effects (quit rates) in the average scenario.

Unit cost: €2.53 Costs of interventions in current practice based on Dutch empirical data Cost calculations of interventions in increased implementation program based on Dutch practice guidelines and (for the duration of NRT and bupropion) on international trials (Cochrane meta-analysis) Costs of smoking-related diseases were taken into account, estimates based on Dutch cost-ofillness study that allocated total direct health care costs to diseases.
Unit cost: €2.53 Costs of interventions in current practice based on Dutch empirical data Cost calculations of interventions in increased implementation program based on Dutch practice guidelines and (for the duration of NRT and Buproprion) on international trials (Cochrane meta-analysis) Costs of smoking-related diseases were taken into account, estimates based on Dutch cost-ofillness study that allocated total direct health care costs to diseases.

patients remain on one type of treatment throughout their smoking cessation therapy costs and consequences of side-effects of bupropion or NRT were not taken into account
patients remain on one type of treatment throughout their smoking cessation therapy costs and consequences of side-effects of Buproprion or NRT were not taken into account

Costs and consequences of side-effects of bupropion or NRT were not taken into account
Costs and consequences of side-effects of Buproprion or NRT were not taken into account

2000 € Minimal counselling by a GP consists of one or two consultations with a total length of 12 minutes, not provided as part of a consultation for other health reasons Minimal counselling+NRT is provided for a period of 8 weeks Intensive counselling+NRT is provided by a trained lung nurse for a total of 90 minutes after a brief advice from a lung physician, period of NRT is 12 weeks Intensive counselling+bupropion included intensive counselling as described above with bupropion for a period of 9 weeks Telephone counselling consists of one intake call of 30 minutes and six follow-up calls of each 15 minutes Costs of self-help materials was included One defined daily dose (DDD) equals 14 mg for NRT patches.
2000 € Minimal counselling by a GP consists of one or two consultations with a total length of 12 minutes, not provided as part of a consultation for other health reasons Minimal counselling+NRT is provided for a period of 8 weeks Intensive counselling+NRT is provided by a trained lung nurse for a total of 90 minutes after a brief advice from a lung physician, period of NRT is 12 weeks Intensive counselling+Buproprion included intensive counselling as described above with Buproprion for a period of 9 weeks Telephone counselling consists of one intake call of 30 minutes and six follow-up calls of each 15 minutes Costs of self-help materials was included One defined daily dose (DDD) equals 14 mg for NRT patches.

Als we Bupropion vergelijken met nicotinevervangende therapie (NVT), is er beperkt bewijs dat Bupropion meer effect heeft, met name 13% meer rokers die stoppen met Bupropion, maar dit werd vastgesteld bij slechts één RCT. 8 Het betrouwbaarheidsinterval is vrij breed en benadert een klinisch weinig relevant niveau (95% CI 2 – 15).
Si l'on compare le Bupropion aux traitements nicotiniques de substitution (TNS), il semble évident que le Bupropion ait certains effets, à savoir 13% d'abstinents en plus avec le Bupropion, mais on ne le trouve que dans un RCT 8 et l'intervalle de confiance est relativement étendu : il s'approche du niveau clinique et devient ininterprétable(95% CI 2 – 15).

hypotensie + memantine: toename van de ongewenste dopaminerge effecten + bupropion: neuropsychische stoornissen (te vermijden) + baclofen: neuropsychische en gastro-intestinale stoornissen (te vermijden) + methyldopa: verhoogt het effect van levodopa (te vermijden)
du risque d’hypotension orthostatique + mémantine: renforcement des effets indésirables dopaminergiques + bupropion: troubles neuropsychiques (à éviter) + baclofène: troubles neuropsychiques et digestifs (à éviter) + methyldopa: augmentation des effets de la lévodopa (à éviter)

Six cost-benefit studies have concluded that these control policies are cost effective in situations where carriage rates on admission vary between 0.5 to 20 %, efficacy of control measures between 14 and 80 % and rate of infection among colonised patients is between 20 and 60 % 13, 14, 15, 16 .
Six études de coût-bénéfice ont conclu que ces politiques de contrôle sont rentables dans des situations où le taux de portage à l’admission varie entre 0,5 et 20 %, l’efficacité des mesures de contrôle entre 14 et 80 % et le taux d'infection chez les patients colonisés entre 20 et 60% 13, 14, 15, 16 .

Lederle F, Busch D, Mattox K et al. Cost-effective treatment in the elderly. A randomized double-blind comparison of sorbitol and lactulose.
A randomized double-blind comparison of sorbitol and lactulose.