Traduction de «analysis breast cancer mortality reduction » (Néerlandais → Français) :

Table 7: Evidence form systematic reviews and meta analysis (breast cancer mortality reduction in intervention group) Study ID Ref Population Intervention Results of meta-analysis Comments Level of evidence
Table 9: Evidence form systematic reviews and meta analysis (breast cancer mortality reduction in intervention group) Study ID Ref Population Intervention Results of meta-analysis Comments Level of evidence

50. Miller Ab TTBCJWC. The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up.
49. Miller Ab TTBCJWC. The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up.

19. Miller AB, To T, Baines CJ, Wall C. The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up.
20. Miller AB, To T, Baines CJ, Wall C. The Canadian National Breast Screening Study-1: breast cancer mortality after 11 to 16 years of follow-up.

44. Olsen A, Njor HS, Vejborg I, Schwartz W, Dalgaard P, Jensen M-B, et al. Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study.
43. Olsen A, Njor HS, Vejborg I, Schwartz W, Dalgaard P, Jensen M-B, et al. Breast cancer mortality in Copenhagen after introduction of mammography screening: cohort study.

57. Van Dijck JA, Verbeek AL, Beex LV, Hendriks JH, Holland R, Mravunac M, et al. Breast-cancer mortality in a non-randomized trial on mammographic screening in women over age 65.
56. Van Dijck JA, Verbeek AL, Beex LV, Hendriks JH, Holland R, Mravunac M, et al. Breast-cancer mortality in a non-randomized trial on mammographic screening in women over age 65.

Spontaneous cessation rate: 2.5% OR counselling only: 1.73 Incremental OR NRT gum (relative to counselling only): 1.63 Incremental OR NRT patch (relative to counselling only): 1.79 Incremental OR NRT spray (relative to counselling only): 2.35 Incremental OR NRT inhaler (relative to counselling only): 2.14 Incremental OR bupropion (relative to counselling only): 2.30 % of smokers still under treatment after the first month: 50% (range 40-60% in sensitivity analysis) % of smokers still under treatment after the second month: 20% (range 15-25% in sensitivity analysis) Lifetime relapse probability after one year of abstinence: 35% (range 10-50% in sensitivity analysis) Effect of smoking cessation on mortality derived from the results of the American Cancer Society Prevention Study II. The mortality rate for former smokers was projected by calculating a weighted average of the incremental differentials between mortality rates of neversmokers and smokers, weighted according to the duration of abstinence.
Spontaneous cessation rate: 2.5% OR counselling only: 1.73 Incremental OR NRT gum (relative to counselling only): 1.63 Incremental OR NRT patch (relative to counselling only): 1.79 Incremental OR NRT spray (relative to counselling only): 2.35 Incremental OR NRT inhaler (relative to counselling only): 2.14 Incremental OR Buproprion (relative to counselling only): 2.30 % of smokers still under treatment after the first month: 50% (range 40-60% in sensitivity analysis) % of smokers still under treatment after the second month: 20% (range 15-25% in sensitivity analysis) Lifetime relapse probability after one year of abstinence: 35% (range 10-50% in sensitivity analysis) Effect of smoking cessation on mortality derived from the results of the American Cancer Society Prevention Study II. The mortality rate for former smokers was projected by calculating a weighted average of the incremental differentials between mortality rates of neversmokers and smokers, weighted according to the duration of abstinence.

Breast cancer (age group 40 - 49): observed and estimated specific mortality rate / 100 000 women per year in Flanders (Belgium) (1999-2006)
Breast cancer (age group 40 - 49) : observed and estimated specific mortality rate / 100 000 women per year in Flanders (Belgium) (1999-2006)

Diovan/Co–Diovan Hypertension 657 0 895 2 1 552 1 1 Gleevec/Glivec Chronic myeloid leukemia 319 19 756 4 1 075 9 8 Zometa Cancer complications 184 6 194 6 378 5 6 Lucentis Age-related macular degeneration 377 29 377 28 29 Femara Breast cancer 163 16 175 7 338 9 10 Sandostatin Acromegaly and neuroendocrine tumors 125 12 187 10 312 11 11 Exelon/Exelon Patch Alzheimer’s disease 103 17 149 5 252 8 9 Exforge Hypertension 72 26 155 43 227 35 37 Neoral/Sandimmun Transplantation 20 0 197 -5 217 -4 -5 Voltaren (excl. OTC) Inflammation/pain 200 2 200 1 2 Top ten products total 1 643 8 3 285 7 4 928 7 7 Exjade Iron chelator 70 -7 122 25 192 11 11 Comtan/Stalevo Parkinson’s disease 60 11 90 8 150 9 9 Reclast/Aclasta Osteoporosis 99 24 43 22 142 23 23 Ritalin/Focalin Attention Deficit/Hyperactivity Disorder 89 7 31 16 120 9 8 Lescol Cholesterol reduction 25 -17 87 -26 112 -24 -24 Myfortic Transplantation 40 18 68 19 108 20 18 Tekturna/Rasilez Hypertension 50 25 53 98 103 54 56 Tegretol Epilepsy 19 -5 72 -2 91 0 -1 Foradil Asthma 10 400 78 -8 88 0 2 Xolair Asthma 8 -62 82 47 90 14 18 Top 20 products total 2 113 8 4 011 8 6 124 8 8 Rest of portfolio 459 0 1 087 12 1 546 9 8 Total Division sales 2 572 7 5 098 9 7 670 8 8
Diovan/Co–Diovan Hypertension 657 0 895 2 1 552 1 1 Glivec/Gleevec Leucémie myéloïde chronique 319 19 756 4 1 075 9 8 Zometa Complications des cancers 184 6 194 6 378 5 6 Lucentis Dégénérescence maculaire liée à l’âge 377 29 377 28 29 Femara Cancer du sein 163 16 175 7 338 9 10 Sandostatine Acromégalie et tumeurs neuroendocrines 125 12 187 10 312 11 11 Exelon/Exelon Patch Maladie d’Alzheimer 103 17 149 5 252 8 9 Exforge Hypertension 72 26 155 43 227 35 37 Sandimmun/Neoral Transplantation 20 0 197 -5 217 -4 -5 Voltaren (hors OTC) Etats inflammatoires/douleurs 200 2 200 1 2 Total des dix premiers produits 1 643 8 3 285 7 4 928 7 7 Exjade Chélateur du fer 70 -7 122 25 192 11 11 Comtan/Stalevo Maladie de Parkinson 60 11 90 8 150 9 9 Reclast/Aclasta Ostéoporose 99 24 43 22 142 23 23 Ritaline/Focaline Déficit de l’attention/troubles d’hyperactivité 89 7 31 16 120 9 8 Lescol Hypercholestérolémie 25 -17 87 -26 112 -24 -24 Myfortic Transplantation 40 18 68 19 108 20 18 Rasilez/Tekturna Hypertension 50 25 53 98 103 54 56 Tegretol Epilepsie 19 -5 72 -2 91 0 -1 Foradil Asthme 10 400 78 -8 88 0 2 Xolair Asthme 8 -62 82 47 90 14 18 Total des vingt premiers produits 2 113 8 4 011 8 6 124 8 8 Reste du portefeuille 459 0 1 087 12 1 546 9 8 Total chiffre d’affaires de la division 2 572 7 5 098 9 7 670 8 8

Diovan/Co–Diovan Hypertension 1 872 2 2 605 0 4 477 2 1 Gleevec/Glivec Chronic myeloid leukemia 938 19 2 184 3 3 122 9 8 Lucentis Age-related macular degeneration 1 139 30 1 139 33 30 Zometa Cancer complications 538 0 578 5 1 116 4 3 Femara Breast cancer 491 16 534 6 1 025 11 11 Sandostatin Acromegaly and neuroendocrine tumors 371 11 569 11 940 12 11 Exelon/Exelon Patch Alzheimer’s disease 290 10 457 7 747 9 8 Exforge Hypertension 211 27 442 43 653 37 37 Neoral/Sandimmun Transplantation 62 -6 574 -8 636 -6 -8 Voltaren (excl. OTC) Inflammation/pain 1 -67 586 2 587 2 1 Top ten products total 4 774 8 9 668 6 14 442 8 7 Exjade Iron chelator 197 10 356 22 553 18 17 Comtan/Stalevo Parkinson’s disease 172 9 271 9 443 10 9 Reclast/Aclasta Osteoporosis 278 22 130 31 408 26 25 Ritalin/Focalin Attention Deficit/Hyperactivity Disorder 250 -2 89 15 339 3 2 Lescol Cholesterol reduction 73 -19 257 -24 330 -22 -23 Myfortic Transplantation 120 21 210 27 330 29 25 Tekturna/Rasilez Hypertension 148 24 157 94 305 51 53 Tasigna Chronic myeloid leukemia 89 102 184 83 273 90 89 Galvus Diabetes 267 136 267 132 136 Xolair Asthma 19 -66 248 56 267 22 24 Top 20 products total 6 120 8 11 837 10 17 957 10 9 Rest of portfolio 1 396 -2 3 173 0 4 569 1 0 Total Division sales 7 516 6 15 010 8 22 526 8 7
Diovan/Co–Diovan Hypertension 1 872 2 2 605 0 4 477 2 1 Glivec/Gleevec Leucémie myéloïde chronique 938 19 2 184 3 3 122 9 8 Lucentis Dégénérescence maculaire liée à l’âge 1 139 30 1 139 33 30 Zometa Complications des cancers 538 0 578 5 1 116 4 3 Femara Cancer du sein 491 16 534 6 1 025 11 11 Sandostatine Acromégalie et tumeurs neuroendocrines 371 11 569 11 940 12 11 Exelon/Exelon Patch Maladie d’Alzheimer 290 10 457 7 747 9 8 Exforge Hypertension 211 27 442 43 653 37 37 Sandimmun/Neoral Transplantation 62 -6 574 -8 636 -6 -8 Voltaren (hors OTC) Etats inflammatoires/douleurs 1 -67 586 2 587 2 1 Total des dix premiers produits 4 774 8 9 668 6 14 442 8 7 Exjade Chélateur du fer 197 10 356 22 553 18 17 Comtan/Stalevo Maladie de Parkinson 172 9 271 9 443 10 9 Reclast/Aclasta Ostéoporose 278 22 130 31 408 26 25 Ritaline/Focaline Déficit de l’attention/troubles d’hyperactivité 250 -2 89 15 339 3 2 Lescol Hypercholestérolémie 73 -19 257 -24 330 -22 -23 Myfortic Transplantation 120 21 210 27 330 29 25 Rasilez/Tekturna Hypertension 148 24 157 94 305 51 53 Tasigna Leucémie myéloïde chronique 89 102 184 83 273 90 89 Galvus Diabète 267 136 267 132 136 Xolair Asthme 19 -66 248 56 267 22 24 Total des vingt premiers produits 6 120 8 11 837 10 17 957 10 9 Reste du portefeuille 1 396 -2 3 173 0 4 569 1 0 Total chiffre d’affaires de la division 7 516 6 15 010 8 22 526 8 7

Diovan/Co–Diovan Hypertension 627 4 856 0 1 483 1 2 Gleevec/Glivec Chronic myeloid leukemia 333 22 682 -1 1 015 4 6 Lucentis Age-related macular degeneration 398 22 398 19 22 Zometa Cancer complications 176 -5 187 0 363 -3 -3 Femara Breast cancer 169 13 174 1 343 4 6 Sandostatin Acromegaly and neuroendocrine tumors 124 6 194 9 318 6 8 Exelon/Exelon Patch Alzheimer’s disease 89 -8 155 5 244 -3 0 Exforge Hypertension 73 22 149 40 222 30 33 Neoral/Sandimmun Transplantation 20 0 187 -9 207 -9 -8 Voltaren (excl. OTC) Inflammation/pain nm 202 1 202 -1 0 Top ten products total 1 611 7 3 184 4 4 795 4 5 Exjade Iron chelator 65 7 117 8 182 5 7 Comtan/Stalevo Parkinson’s disease 58 9 94 9 152 8 9 Reclast/Aclasta Osteoporosis 100 12 43 22 143 14 15 Ritalin/Focalin Attention Deficit/Hyperactivity Disorder 71 -11 29 11 100 -6 -5 Lescol Cholesterol reduction 24 -17 79 -25 103 -24 -24 Myfortic Transplantation 43 19 79 37 122 31 30 Tekturna/Rasilez Hypertension 55 20 58 72 113 36 42 Tasigna Chronic myeloid leukemia 36 100 73 93 109 95 97 Galvus Diabetes 101 114 101 102 114 Xolair Asthma 11 -35 86 42 97 24 32 Top 20 products total 2 074 7 3 943 8 6 017 6 8 Rest of portfolio 490 1 1 058 2 1 548 0 1 Total Division sales 2 564 6 5 001 6 7 565 5 6
Diovan/Co–Diovan Hypertension 627 4 856 0 1 483 1 2 Glivec/Gleevec Leucémie myéloïde chronique 333 22 682 -1 1 015 4 6 Lucentis Dégénérescence maculaire liée à l’âge 398 22 398 19 22 Zometa Complications des cancers 176 -5 187 0 363 -3 -3 Femara Cancer du sein 169 13 174 1 343 4 6 Sandostatine Acromégalie et tumeurs neuroendocrines 124 6 194 9 318 6 8 Exelon/Exelon Patch Maladie d’Alzheimer 89 -8 155 5 244 -3 0 Exforge Hypertension 73 22 149 40 222 30 33 Sandimmun/Neoral Transplantation 20 0 187 -9 207 -9 -8 Voltaren (hors OTC) Etats inflammatoires/douleurs 202 1 202 -1 0 Total des dix premiers produits 1 611 7 3 184 4 4 795 4 5 Exjade Chélateur du fer 65 7 117 8 182 5 7 Comtan/Stalevo Maladie de Parkinson 58 9 94 9 152 8 9 Reclast/Aclasta Ostéoporose 100 12 43 22 143 14 15 Ritaline/Focaline Déficit de l’attention/troubles d’hyperactivité 71 -11 29 11 100 -6 -5 Lescol Hypercholestérolémie 24 -17 79 -25 103 -24 -24 Myfortic Transplantation 43 19 79 37 122 31 30 Rasilez/Tekturna Hypertension 55 20 58 72 113 36 42 Tasigna Leucémie myéloïde chronique 36 100 73 93 109 95 97 Galvus Diabète 101 114 101 102 114 Xolair Asthme 11 -35 86 42 97 24 32 Total des vingt premiers produits 2 074 7 3 943 8 6 017 6 8 Reste du portefeuille 490 1 1 058 2 1 548 0 1 Total chiffre d’affaires de la division 2 564 6 5 001 6 7 565 5 6