A study appearing in Pharmacoepidemiology and Drug Safety in 1995 demonstrated that from 1974 to 1993, ten products were withdrawn from circulation in the U.S., while from 1997 to 2001, after the introduction of user fees, there were 12 withdrawals, including nine drugs that were approved after 1992.
Une étude parue dans Pharmacoepidemiology and Drug Safety en 1995 démontrait que de 1974 à 1993, 10 produits ont été retirés de la circulation aux États-Unis, alors que de 1997 à 2001, après l'introduction des frais aux usagers, il y a eu 12 retraits, dont 9 médicaments qui avaient été approuvés après 1992.